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Soluble Neuregulin-4(NRG4) ELISA, Protein Antibody

New Biomarkers for Metabolic Syndrome Research

Alternative name:

  • Neuregulin
  • Pro-NRG4
  • Heregulin
  • HRG4

Soluble Neuregulin-4 (Human) ELISA Kit had been used by Dr. Zhang H on following research

Circulating neuregulin 4 levels are inversely associated with subclinical cardiovascular disease in obese adults

Neuregulin 4 (Nrg4) has been identified as a new secreted adipokine that may protect against development of obesity and metabolic disorders. However, information is not available regarding the association between circulating Nrg4 and subclinical atherosclerosis in humans. We measured serum Nrg4 in 485 obese adult subjects (aged 40 years or older) who had the measurement of carotid intima-media thickness (CIMT) recruited from the community. Individuals with increased CIMT and carotid plaque had lower levels of circulating Nrg4 than controls (p < 0.05). The risks of increased CIMT and atherosclerotic plaque were significantly decreased by 28% and 31% [OR (95% CI): 0.72 (0.53-0.98) and 0.69 (0.50-0.96), respectively], adjusting for age, sex, current smoking, alcohol consumption, physical activity, BMI, systolic BP, fasting glucose, total cholesterol, HDL-c, HOMA-IR, and body fat. Importantly, individuals in the lowest quartile of serum Nrg4 were 3.70 times (p < 0.001) more likely to have increased CIMT and 2.06 times (p < 0.05) more likely to have atherosclerotic plaque than those in the highest quartile in multivariable logistic regression analyses. These findings suggest that circulating Nrg4 concentrations are inversely associated with subclinical atherosclerosis in obese adults, and indicating that circulating Nrg4 might play a role in identifying patients at high risk for CVD.
Jiang J, Lin M, Xu Y, Shao J, Li X, Zhang H, Yang S. Sci Rep. 2016 Nov 7;6:36710. doi: 10.1038/srep36710.]

Association of circulating neuregulin 4 with metabolic syndrome in obese adults: a cross-sectional study.

BACKGROUND:Neuregulin 4 (Nrg4) is a secreted adipokine recently identified as playing an important role in modulating systemic energy metabolism and the development of obesity-associated disorders. However, information is not available regarding the association between circulating Nrg4 and risk of metabolic syndrome (MetS) in humans. METHODS: We measured serum Nrg4 in 1212 obese adult subjects (aged 40 years or older), with a waist circumference greater than 90 cm for men or 80 cm for women, recruited from the community. RESULTS: MetS subjects had lower levels of circulating Nrg4 than healthy controls (P < 0.01). The prevalence of MetS was higher in subjects with lower levels of circulating Nrg4 compared to those with higher values (67.3 % vs. 57.4 %, P < 0.05). Likewise, subjects with low levels of circulating Nrg4 had high prevalence of raised fasting glucose and blood pressure, but there was no association with raised triglycerides and reduced HDL-c. In multivariable logistic regression analyses, increased serum Nrg4 was significantly associated with reduced risk of MetS (OR: 0.603; 95 % CI, 0.439-0.828; P = 0.002), adjusting for age, gender, current smoking, alcohol consumption, physical activity, BMI, systolic blood pressure, fasting glucose, triglyceride, HDL-c, HOMA-IR, and body fat mass; however, such associations with serum Nrg4 were not noted for each component of MetS. CONCLUSIONS: These findings indicate that circulating Nrg4 concentrations are inversely associated with risk of MetS in obese Chinese adults, suggesting that circulating Nrg4 concentrations may be a protective factor in the development of MetS.
Cai C, Lin M, Xu Y, Li X, Yang S, Zhang H.BMC Med. 2016 Oct 24;14(1):165.
soluble NRG4 ELISA Kit Soluble Neuregulin-4 (sNRG4) ELISA Kit
Code No.: SK00555-06
Size: 96 T
Price: $490.00 USD
Standard range:0.25 - 32 ng/ml
Sensitivity: 125 pg/ml
Sample Type: serum, plasma
sample require: 100 uL per well
Intra-CV: 4-6%
Inter-CV: 8-10%
Data Sheet: PDF
  Soluble Neuregulin-4 (sNRG4) ELISA Kit
Code No.: SK00555-08
Size: 96 T
Price: $590.00 USD
Standard range:250-16000 pg/ml
Sensitivity: 98 pg/ml
Excitation/ Emission : 535nm/625nm
Sample Type: serum, plasma
sample require: 100 uL per well
Intra-CV: 6-9%
Inter-CV: 8-14%
Data Sheet: PDF
  Soluble Neuregulin-4 (sNRG4) ELISA Kit
Code No.: SK00555-07
Size: 96 T
Price: $590.00 USD
Standard range:250-16000 pg/ml
Sensitivity: 98 pg/ml
Excitation/ Emission : 535nm/625nm
Sample Type: serum, plasma
sample require: 100 uL per well
Intra-CV: 6-9%
Inter-CV: 8-14%
Data Sheet: PDF
soluble NRG4 elisa kit SK00555-09 Soluble Neuregulin-4 (sNRG4) ELISA Kit
Code No.: SK00555-09
Size: 96 T
Price: $590.00 USD
Standard range:250-8000 pg/ml
Sensitivity: 100 pg/ml
Excitation/ Emission : 320 nm/430 nm
Sample Type: serum, plasma
sample require: 100 uL per well
Intra-CV: 6-9%
Inter-CV: 8-14%
Data Sheet: PDF
Human Soluble Neuregulin-4 Recombinant
Code No.: 00555-01-100
Size: 100 ug
Price: $360.00 USD
Protein ID:NP_612640.1
Gene ID: NM_138573.3
MW:10 KD
Tag: His Tag on N-Terminus
Expressed: E. Coli
Purity: 95%
Data Sheet: PDF
 

 

Name
Code No.
Size
Price ($)
Soluble Neuregulin-4 (sNRG4) (Human) ELISA Kit SK00555-06 96 T 490.00
Soluble Neuregulin-4 (sNRG4) (Human) ELISA Kit SK00555-09 96 T 540.00
Soluble Neuregulin-4 (sNRG4) (Human) ELISA Kit SK00555-07 96 T 590.00
Soluble Neuregulin-4 (sNRG4) (Human) ELISA Kit SK00555-08 96 T 590.00
Soluble Neuregulin-4 (sNRG4) (Human) Recombinant 00555-01-100 100 ug 360.00
Rabbit Anti Soluble Neuregulin-4 (sNRG4) (Human) IgG A00555-01-100 100 ug 360.00
Rabbit Anti Soluble Neuregulin-4 (sNRG4) (Human) IgG Biotinylated A00555-12-50B 50 ug 360.00