Myeloid-Derived Growth Factor (MYDGF)/SF20/IL-25 ELISA,Antibody, Protein |
- IL-25
- IL-27W
- IL-27
- Stromal Cell-Derived Growth Factor SF20
- C19orf10
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Paracrine-acting proteins are emerging as a central mechanism by which bone marrow cell-based therapies improve tissue repair and heart function after myocardial infarction (MI). We carried out a bioinformatic secretome analysis in bone marrow cells from patients with acute MI to identify novel secreted proteins with therapeutic potential. Functional screens revealed a secreted protein encoded by an open reading frame on chromosome 19 (C19orf10) that promotes cardiac myocyte survival and angiogenesis. We show that bone marrow-derived monocytes and macrophages produce this protein endogenously to protect and repair the heart after MI, and we named it myeloid-derived growth factor (MYDGF). Whereas Mydgf-deficient mice develop larger infarct scars and more severe contractile dysfunction compared to wild-type mice, treatment with recombinant Mydgf reduces scar size and contractile dysfunction after MI. This study is the first to assign a biological function to MYDGF, and it may serve as a prototypical example for the development of protein-based therapies for ischemic tissue repair.
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Korf-Klingebiel M, et al. Nat Med. 2015 Feb;21(2):140-9
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Code No.:SK00579-06
Size: 96 T
Price: $560.00 USD
Standard range:3.9 - 250 pg/ml
Sensitivity: 5 pg/ml
Specificity: human MDGF
Sample type: serum, EDTA plasma
Dilution Factor: N/A
Intra-CV: 4-6%
Inter-CV: 8-10%
Protein ID:NP_061980.1
Gene ID: NM_019107.3
Data Sheet: PDF
Fluorescent Reader require: 325/420nm |
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Code No.:SK00579-03
Size: 96 T
Price: $560.00 USD
Standard range:7.8 - 250 pg/ml
Sensitivity: 5 pg/ml
Specificity: Mouse MDGF
Sample type: serum, EDTA plasma
Dilution Factor: N/A
Intra-CV: 4-6%
Inter-CV: 8-10%
Protein ID:NP_543027.1
Gene ID:NM_080837.2
Data Sheet: PDF
Fluorescent Reader require: 325/420nm |
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Code No.:SK00579-01
Size: 96 T
Price: $460.00 USD
Standard range:31.25-2000 pg/ml
Sensitivity: 15 pg/ml
Specificity: human MDGF
Sample type: serum, EDTA plasma
Dilution Factor: N/A
Intra-CV: 4-6%
Inter-CV: 8-10%
Protein ID:NP_061980.1
Gene ID: NM_019107.3
Data Sheet: PDF |
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Code No.: 00579-04-10
Size: 10 ug
Price: $210.00 USD
Protein ID:NP_061980.1
Gene ID: NM_019107.3
MW: 55 KD
Tag: His Tag on c-Terminus
Expressed: HEK293 cells
Purity: 95%
Data Sheet: PDF |
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Code No.: 00579-02-5
Size: 5 ug
Price: $120.00 USD
Protein ID:NP_061980.1
Gene ID: NM_019107.3
MW: 55 KD
Tag: His Tag on c-Terminus
Expressed: HEK293 cells
Purity: 95%
Data Sheet: PDF |
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Code No.: 00579-02-10
Size: 10 ug
Price: $210.00 USD
Protein ID:NP_061980.1
Gene ID: NM_019107.3
MW: 55 KD
Tag: His Tag on c-Terminus
Expressed: HEK293 cells
Purity: 95%
Data Sheet: PDF
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Code No.: 00579-11-10
Size: 10 ug
Price: 220 USD
Protein ID:NP_543027.1
Gene ID:NM_080837.2
MW: 30-35 KD
Tag: His tag on C-terminus
Expressed: HEK293 cells
Purity: 95%
Data Sheet: PDF |
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Code No.: 00579-05-10
Size: 10 ug
Price: 260 USD
Protein ID:NP_543027.1
Gene ID:NM_080837.2
MW: 16 KD
Tag: N/A
Expressed: E. Coli
Purity: 95%
Data Sheet: PDF |
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Code No.: 00579-05-1000
Size: 1 mg
Price: Inquire
Protein ID:NP_543027.1
Gene ID:NM_080837.2
MW: 16 KD
Tag: N/A
Expressed: E. Coli
Purity: 95%
Data Sheet: PDF |